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rpsB [2020-05-27 09:18:26]
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rpsB [2020-05-27 09:18:26]

ribosomal protein
locus
BSU_16490
pI
6.00
mw
27.00 kDa
protein length
246 aa Sequence Blast
gene length
741 bp Sequence Blast
function
translation
product
ribosomal protein S2
essential
yes
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]

    • Gene

    Coordinates
    1,717,933 → 1,718,673

    Phenotypes of a mutant

  • essential [Pubmed|23002217,12682299]

    • The protein

    Protein family

  • universal [SW|ribosomal protein] uS2 family (single member, according to UniProt)

    • Structure

  • [PDB|3J9W] (the [SW|ribosome]) [Pubmed|25903689]

    • [SW|Localization]

  • [SW|ribosome], at the dimer interface of hibernating ribosomes to prevent loss of the protein [pubmed|32123037]

    • additional information

  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

    • Expression and Regulation

    Operons

    genes
    [gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, [Pubmed|11948165], in [regulon|stringent response|stringent response]
  • [protein|F1969E4C7BAAF70BCBE570F58350C12A3E417539|RpsB]: autorepression, [pubmed|32448158], in [regulon|F1969E4C7BAAF70BCBE570F58350C12A3E417539|RpsB regulon]

    • regulation

  • autorepression of ''rpsB'' expression upon binding of excess [protein|F1969E4C7BAAF70BCBE570F58350C12A3E417539|RpsB] to a [SW|RNA switch] in the untranslated region of the ''rpsB'' mRNA [Pubmed|32448158]
  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
    • view in new tab

    genes
    [gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB]-[gene|94E1130A787CBCCCDBDA93C8AFC24ECB82D5FE61|tsf]-[gene|40655595D0C573B4CB75FB255CBB01A6ACF1F94D|pyrH]-[gene|093960C48AD50C0D0B3A68BBFE7D060BE716935D|frr]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, [pubmed|11948165], in [regulon|stringent response|stringent response]

    • regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
    • view in new tab

    Biological materials

    lacZ fusion

  • pGP602 (in [SW|pAC6]), available in [SW|Stülke] lab

    • References

  • 18763711,19653700,23002217,15378759,25903689,27120414,28468753,28516784,32123037